Page 159 - CW E-Magazine (10-6-2025)

Special Report

Adoption of electrochemistry as the base and the reaction temperature beta- and gamma-G have found place in
within the pharmaceutical was 90°C. The conversion of SA was energy harvesting. Piezoelectric charac-
industry; Insights from an 100% and MS yield was 96%. DMS teristics are discussed. (Chem. Eng. Jl.,
industry-wide survey acted as a solvent as well. H SO was 2025; DOI: 10.1016/j.cej.2025.161514,
2
4
neutralized to make Na SO with NaOH. 510, 15April, 1615143).
2
4
A.C. Ferretti et al have reported results (ACS Omega, 2025; DOI: 10.1021/
of a comprehensive survey among acsomega.4c100962). Agrochemicals
17 major pharmaceutical companies.
Aspects of motivation, vision, personnel, TEMPO-mediated paired electro- Designs, synthesis and micro-
utilization, explored reaction, scale-up synthesis of ethylene glycol bial activity evaluation of novel
experience, and equipment are covered (EG) from HCHO and CH OH tetrahydrocarbazole (THC)
3
with a focus on identifying gaps that at high current densities derivatives against phytopatho-
hinder the realization of electrochemi- genic fungi and bacteria
stry’s full potential. The use of elec- T. Wirtanen et al have reported that
trochemistry is still in its early stages, the use of TEMPO accentuates HCHO Y.Y. Ding et al have stressed that
and it is accepted as a promising area. production at the anode, providing addi- plant pathogenic bacteria and fungi
(This column has covered many electro- tional HCHO for pinacol coupling at the have a wide impact on various crops
chemistry based processes). None cathode. The media is water/methanol and have resulted in serious economic
of the companies have commercialized solution and a simple undivided cell losses. Alkaloids are noteworthy for
electrochemical processes but some are using sulphuric acid treated graphite pharmacological activities. A novel
at late stages. (Org. Proc. Res. Dev., electrodes is used. The industrially feasi- drug-like chemical entity based on
2025; DOI: 10.1021/acs.oprd.4c 00353). ble current densities between 300 to 350 THC was evaluated for antimicrobial
mA are adopted. The conditions of batch activities of these derivatives against
Separation of polycotton for reaction were successfully transferred plant pathogenic bacteria and fungi.
textile recycling using the DBU/ to a continuous fl ow-cell arrangement. Structures of the above derivatives are
DMSO/CO switchable solvent (ChemSusChem, 2025; DOI: 10.1002/ given in the paper. These products have
system 2 cssc.202500123). shown favorable activity, and the lead
molecule is referred. (Pest Management
M. Jungbluth and S. Beuermann have The hidden power of glycine (G) Sci., 2025, 81, issue 4, 1752-1764; DOI:
worked on the title problem of textile 10.1002/ps.8567).
waste with reference of blends of diff e- L. Nascimento et al have reported that
rent fibers such as polycotton. The this small amino acid has high potential Tymirium technology: The
separation of polyester and cotton will for piezoelectric and piezo-triboelectric discovery of Cyclobutrifl uram
allow recycling. The selective dissolu- nanogenerators. G polymorphs proper- (CBTF)
tion of cotton using a switchable solvent ties are covered; alpha, beta and gamma
consisting of 1,8-diazobicyclo[5.4.0.] have distinct functional properties. Syngenta has stressed the agricultural
undec-7-ene (DBU), DMSO, and CO Alpha-G is used in pharmaceuticals; loss by nematodes (which are also
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is reported. Ethanol allows precipita- present in several locations in India and
tion of cotton. (ACS Sustainable Chem. some older generation products have
Eng., 2025; DOI: 10.1021/acssusche- been banned). This resulted in the deve-
meng.4c07533). lopment of CBTF technology which is
a nematocide and fungicide solution.
Dimethyl sulfate (DMS) for CBTF is a chiral phenyl cyclobutyl
selective in Methylation of pyridineamide and has demonstrated its
salicylic acid (SA) to methyl wide-ranging eff ectiveness against all
salicylate (MS) economically important parasitic nema-
todes, and several soil-borne diseases,
M. deSouza Freitas et al have reported particularly those caused by Fusarium
the title regioselective methylation at – species. (Pest Management Sci., 2025,
COOH. This was done with NaHCO 26Feb.; DOI: 10.1002/ps.8730).
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158 Chemical Weekly June 10, 2025 Chemical Weekly June 10, 2025 159

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