Page 160 - CW E-Magazine (23-4-2024)

Special Report Special Report

Fenofi brate (FF) and Dalcetrapib (DCP), bicyclo[4.1.0]heptane to give 82% on
and their isolation to the dry state via a 44.8 kg scale. The previous method
AS crystallisation followed by FD. Addi- required high temperature of 490-520°C
tives such as poly(vinyl alcohol) or and gave low yield. After the subsequent
hydroxyl propyl methyl cellulose and Diels-Alder reaction, the process pro-
sodium docusate were used to stabilise ceeds in one step via the condensation
nanoparticles in the range of 200-300 of anhydride and benzohydrazine inter-
nm. Here, most stable particle size dis- mediates to produce the fi nal product in
tribution was realised with multiple ad- a 48% overall yield. 60-kg batch was Flow chart of preparation of CMS membrane
ditives. Desirable properties of the APIs made with a satisfactory quality. (Org. Carbon molecular sieve mem- NaCl, glucose and sucrose were 96.5,
were realised. (Org. Proc. Res. Dev., Proc. Res. Dev., 2023; DOI: 10.1021/ branes (CMSMs) with rationally 95.3, 53.7, 91.7 and 98.2 % respective-
2023; DOI: 10.1021/acs.opr.3C00204). acs.oprd.3C00151). designed polymer processor for ly. (Ind. Eng. Chem. Res., 2023; DOI:
Monitoring drug substance Carbonic anhydrase (CA) ro- improved propane/propylene 10.1021/acs.iecr.3C02326).
drying with online GC chemical production. There is a frequent promising solvent for the ED separation bustness for use in nanoscale separation Liquid phase selective adsorp-
reference to D&A as mature technolo- of 1-butene from 1,3-butadiene. (AIChE [The title separation is of great industrial
T.C. Malig et al have reported a tech- gies. However, their signifi cance is so Jl., 2023; DOI:10.1002/aic.18236). CO capture technologies importance as in cryogenic distillation tion of xylene (X) isomers in ultra-
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nique of monitoring the drying of drug great that small increases in process effi - [CA is essential in human body to capital and energy costs are high. This microporous carbon spheres
substances in agitated fi lter-dryers where ciency have a very large impact. There is Recovery of 2,3-butanediol catalyse the desorption of CO at a column has covered papers on this sub- [X isomers are separated on multi-
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online GC was leveraged to perform further scope in new technologies such (BD) from fermentation broth rapid rate when we indulge in exercise. ject based on adsorptive separation.] million tonnes per annum scale glo-
unattended sampling of the headspace as additive manufacturing and Artifi cial by zeolitic imidazolate frame- Attempts were made to use CA, ex-ox bally; OX is separated by distillation,
throughout drying. Tests were done Intelligence (AI). Rigorous steady-state works blood, for absorbing CO in potash solu- J. Zhang et al have used CMSMs, which but MX and PX have to be separated,
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with Naproxen Sodium, using a ternary and dynamic models have become [BD was made by fermentation during tions in submarines and space shuttles in have excellent chemical and physical which is carried out by adsorption or
standard these days, but prediction of the Second World War to provide a 1960’s. CA is an extraordinary catalyst stability. Here the chemical structure of crystallisation.]
separation effi ciency or fl exible plant feedstock for butadiene required to make for CO absorption in potash solutions, the polymer precursor greatly infl uences S. Chen et al have synthesised glu-
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behaviour remain a challenge. AI will synthetic rubber.] but degrades during desorption due to the separation. These authors have used cose-based adsorbent (UMC-Xyl),
make an impact. Vapour recompression temperature approaching 130°C.] a benzimidazole-based polyimide to which has a remarkable selectivity
or the use of heat pumps in the context The recovery of BD from fermentation make CMSMs. This provides a fl at chain for PX/MX of 53 and with PX uptake
of energy integration are being seriously broth is of considerable importance in A. Sharma et al have worked on the structure to construct ultramicropores. of 91-mg per gm. These parameters
considered. Dividing Wall Column making BD, which can also be used to stability of CA enzymes in industrial Further, metal ions are homogeneously outperform a series of commercial ad-
(DWC) continues to be the subject of a make MEK and diacetyl. Y. Chiang et processes. These authors have evaluated embedded and steric hindrance makes it sorbents, including the industrial bench
great deal of work in pursuit of energy al have used two zeolitic imidazolate the thermostability and enzyme activity diffi cult for larger C H to penetrate. The mark, KBaX. The ultramicropore size
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savings. Rotating Packed Beds (RPBS) frameworks – Z1F-8 and ZIF-71 – for of mesophlilic and thermophilic CA selectivity of C H /C H was as high as distributed at 5.8-6.8 Å . Regeneration
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3
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are again in focus for effi cient fl exible adsorption of BD. ZIF-71 was found to variants at different temperature con- 49.3. (Ind. Eng. Chem. Res., 2023; DOI: was studied. [AIChE Jl., 2023, 21 Sep;
st
CO separation. (Chem. Eng. Res. Des., be robust and fi xed-bed measurements ditions in the presence of atmospheric 10.1021/acs.iecr.3C02933). DOI: 10.1002/aic.18246).
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solvent system consisting of MTBE, 2023, 197, September, 581-583). were made. The uptake reaches over gas pollutants like nitrogen oxides and
acetonitrile and isopropyl acetate. Online 100-gm per kg, with negligible uptake of sulphur oxides. Thermostable variants Fabrication of hollow fibre Wet-oxidative desulphurisation
technique can be implemented. (Org. Data-driven integrated design sugars, organic acids, and other alcohols incubated week-long at different tem- nanofi ltration (NF) membrane as a fl exible and greener way for
Proc. Res. Dev., 2023; DOI: 10/1021/ of solvents and extractive distil- present. Regeneration was done with perature condition maintain high level with PVC substrate for the H S removal from acid gases
acs.oprd.3C002440). lation processes (EDP) ethanol. This method merits attention. of activity despite changes in solution removal of chemicals of concern 2
(Ind. Eng. Chem. Res., 2023; DOI: pH due to increase in concentrations
Distillation (D) and Absorp- Z. Wang et al (Prof. K. Sundmacher 10.1021/acs.iecr.3C01925). of NO/SO (which can be minimised). (COC) J. Wurm et al have adopted the TAKA
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tion (A) in the light of current group) have come out with a comput- [ACS Omega, 2023; DOI: 10.1021/ HAX process on a pilot plant under
challenges and new technical er-aided molecular and process design Effi cient large-scale process for acsomega.3C02630). S. Liu et al have used PVC substrate industrially relevant conditions of coke
chances (CAMPD) for the simultaneous design Tecovirimat (T) via Reactive and NF membrane was fabricated via oven gas (COG). A stable plant opera-
interfacial polymerisation of piperazine tion without sulphur precipitation was
[This is from the Special Issue concern- of solvents and ED processes based on Distillation (RD) for the prepa- (PIP) and trimesoyl chloride on the achieved by a suitable choice of the
ing the 12 International Conference on a data-driven modelling strategy. The ration of cycloheptatriene (CP) lumen side of the PVC UF membrane. operating conditions. The solid-free
th
D and A, Sep 2022, Toulose, France.] Artifi cial Neural Network (ANN)-based
process models replaced the physical T is an antiviral drug for treating monkey A gas sweeping method was used. operating window was assessed and a
J-W. Repke has covered this subject models conventionally used in CAMPD. pox and the key intermediate of T, CP Pb(NO ) rejection of 93% is reported redissolution strategy was developed.
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and brought out the importance of D&A This strategy was utilised to come out was effi ciently obtained by E.M. Bonku with a fl ux of about 24 litre per sq.m- (Chemie. Ing. Technic.; DOI: 10.1002/
for green and climate-free CO -neutral with the prediction of acetyl acetone as a et al, via a RD process of 7,7-dichloro- per hour. Rejection of Na SO , MgSO , cite.202300076).
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160 Chemical Weekly April 23, 2024 Chemical Weekly April 23, 2024 161
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