Page 176 - CW E-Magazine (10-9-2024)

Special Report

(=313nm). The H O generation rate Fast fl ow peptides (Ps) synthesis – the usual method of using pure sources
2
2
was as high as 119.50 mm per hour The route to diffi cult peptides of SiO and Al O , which leads to higher
2
2
3
at 20°C and the maximum H O yield and scale up production cost and higher waste gene-
2
2
approached 2,389 mm. This could be a [Peptides are attracting a lot of attention ration. These authors have systematically
way for large scale adoption. (Ind. Eng. due to the pharma industry.] analysed the available literature, which
Chem. Res., 2024; DOI: 1001021/avs. involves several steps. Diffi culties in
iecr.4c01857). M. Nuno et al have referred to peptide the title process have been brought out.
drugs such as semiglutide and tirzepatide (Reaction Chem. Eng., 2024; DOI: 10.1039/
Pyrolysis and gasification of for the treatment of type II diabetes and D4FEOO115).
5-20 mm tyre rubber cubes weight loss. Fast fl ow synthesis can be Tert-butyl nitrite (t-BuONO)
under CO fl ow adopted even for candidate molecules.
2 as a privileged reagent for C-H PRODUCT RANGE
(Chemistry Today, Chimica Oggi, 2024).
Jansen et al have worked with 5, 10, bond (sub)nitration in organic
15 and 20 mm cubes in the temperature High-performance synthetic synthesis
range of 400°C to 1000°C, under CO waxes for sustainable packag- J. Ma et al have referred to nitro com-
2
fl ow. For pyrolysis, heat transfer seems ing ecosystem pounds as important intermediates in
to be the rate limited step in the tempe- medicines, agrochemicals, dyes and
rature range of 800°C to 900°C. The A. Khan et al have referred to packaging polymers. These authors have reviewed
release of gaseous products results in papers which commercially used paraf- the use of t-BuONO for the synthesis of
shattering cubes into sub-mm char frag- fi n waxes to meet the requirements of nitro compounds via a C-H bond radical
ments. Mass transfer becomes limiting water-and oil-resistance, but these waxes strategy. This review covers the type of
above 1200°C. (Reaction Chem. Eng., are not biodegradable. This study has reaction substrates, etc. (New. Jl. Chem.,
2024; DOI: 10.1039/D3RE 00577A). demonstrated the synthesis and per- 2024; DOI: 10.1039/D4NJ01802H).
formance of biobased, biodegradable
Degradation of polycarbonate synthetic waxes with the potential for Nitrosamines (N)
(PC) waste to recover bis- repulpability. These waxes are ensured
phenol A (BPA) and dimethyl by incorporating lactic/glycolic link- The presence of N in several APIs has
carbonate (DMC) using urea as ages into their structure. Kraft paper created problems even at some ppb level
a cheap green catalyst was quoted as an example for coating [This column has covered this subject].
with the above type of waxes. (ACS L. Badia et al have reported the strategy

N. Hu et al have reported a green effi - Sustainable Chem. Eng., DOI: 10.1021/ to assess and control N formation during
the storage of Sitagliptin (S), an im-
cient and solvent-free degradation of PC acssuschemeng.4c04229). portant drug for diabetes. Air exposure,
to BPA and DMC using urea as a cheap secondary amine content, and optimum
green catalyst at 140°C. This allowed Green and low-cost synthesis of pH conditions emerged as the principal
complete conversion of PC with BPA zeolites (Zs) from Kaolin (K):
and DMC yields of 93.4% and 74.7% a promising technology or a trigger factors. S hydrochloride of four
respectively. This degradation system delusion? distinct types was tested. Packaging to
could be reused directly up to 10 times. prevent the ingress of air is the key factor
in avoiding N. (Org. Proc. Res. Dev.,
(Green Chem., 2024, DOI: 10.1039/ I.M. Zdretsov and A.M. Gerasimov have 2024; DOI: 10.1021/acs.oprd.4C00088).
D4GC03205E). worked on the title process in place of
M. Secatto et al have reported risk
assessment study of N in the API
Temozolomide (T). T made by pharma-
ceutical company Cristália is considered.
This study focused on realising a com-
plete and robust risk assessment from
the stages of synthesis and equipment
evaluation to packaging and stability
condition. (Org. Proc. Res. Dev., 2024;
DOI: 10.1021/acs.oprd.3C00487).

176 Chemical Weekly September 10, 2024

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